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It is important to note that, despite these convergent findings, direct mechanistic evidence demonstrating that addictive substances induce depressive phenotypes via specific epigenetic pathways remains extremely limited, with only a few studies providing clear causal links

Most preclinical models fail to fully replicate the chronicity, behavioural complexity and comorbid metabolic and psychiatric conditions observed in human AUD [3,11]

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Neuroprotective and neurotrophic actions: MC4 signaling is implicated in the regeneration and protection of peripheral nerves, as observed in experimental injury and neuropathy models 3

Regular physical activity also helps maintain bowel regularity

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